2024
Annual
Report

Improving Health in Southern California and Beyond

SC CTSI Investment in Translation Research

Financial Investments

$4.078M in follow-on funding

$400K in pilot funding awarded to 6 projects

5 team-building vouchers awarded

4 Safety Net Innovation Award (SNIA) projects awarded to enhance quality & patient care

Investments in Tools and Resources

1,000+ new REDCap users

1,940 active REDCap projects in 2024

97K biospecimens managed and available

10 projects supported by CTSI regulatory consultations

Clinical Trials Unit supported 110 protocols and 1,759 outpatient visits

Success by the Numbers

Research Output

65 grant proposals

148 publications citing CTSI support

31 researchers reported 32 newly-funded grants

106 educational workshops with 1,664 participants across South, Central & Eastside of LA

Ongoing collaboration with Hollywood, Health & Society yielded positive sentiment about public trust in the future of medicine portrayed on 1,310 films & TV episodes

Investigator Outcomes

88% of surveyed investigators say SC CTSI helped achieve their goals

43% of surveyed researchers reported peer-reviewed publications supported by CTSI

27 investigators (28%) reported their work absolutely resulted in at least one Translational Science Benefits Model (TSBM) benefit

60% of surveyed investigators disseminated findings to scientific audiences and 19% disseminated findings to non-scientific audiences

From the Directors

As we take a look back at our impact over the past year, we wanted to thank you for your support of our services and resources. We have added new service offerings, as well as continued to innovate in key areas such as informatics, healthcare delivery science and workforce development, education, and training. 

Our goal is simple – to translate science into solutions for better health. To achieve this, we are thrilled to report we assisted 284 investigators from nine schools in 2024. These projects have catalyzed clinical and community-based research in our neighborhoods, our city, county, and globally. Enclosed, you will find just a few of our highlights, which would not have been possible without the hard work and expert advice of our CTSI staff and faculty who provide services, resources, education and funding to assist researchers at USC and CHLA in every phase of their clinical and community-based work. We look forward to serving you in the future and sharing in your success.

Thomas Buchanan, MD
SC CTSI Director | Principal Investigator

Michele Kipke, PhD
SC CTSI Co-Director | Community Engagement Director

Our Impact

SC CTSI Funding Leads to Transformative Change

A critical pilot grant from the Southern California Clinical and Translational Science Institute (SC CTSI) helped launch Dr. Justin Ichida’s groundbreaking work to develop new treatments for amyotrophic lateral sclerosis (ALS), ultimately leading to national recognition as a senior member of the National Academy of Inventors—just one powerful example of the major impact our research support and funding continues to make.

A team-building voucher from the Southern California Clinical and Translational Science Institute (SC CTSI) was crucial in helping researchers collaborate and establish the Southern California Center for Young Adult Cancer Survivorship Research. This support helped build the center’s identity, credibility, and capacity, laying the foundation for multi-institutional partnerships, trainee development, and future funding.

New Grants are Multidisciplinary in Nature

The funding sources for these grants include 41% from NIH, 41% from non-profits/foundations, 1% from other government contracts, and 1% from USC. Of these newly-funded grants, 79% are multidisciplinary, 43% engage a community partner, and 24% are involve multiple researchers.

Path to Real World Impact

The Translational Science Benefits Model (TSBM) is a framework designed to help researchers demonstrate real world impact in critical domains below. Our annual survey revealed 118 instances of achieved TSBM benefits reported by 27 investigators.

For example, the Southern California Clinical and Translational Science Institute (SC CTSI) supported a pilot study led by Dr. David Armstrong to create a multidisciplinary "hot foot line" team that rapidly assesses and treats diabetic patients with foot ulcers to preserve limbs and prevent amputation.

This "hot foot line" integrates all key specialties involved in diabetic foot care, including vascular and podiatric surgery, endocrinology, nursing, and custom shoe and orthotic design. The model has already shown measurable success, reducing amputation rates and improving outcomes for patients with diabetes. In recognition of his groundbreaking work, USC named Dr. Armstrong a Distinguished Professor in 2025. This is the first time USC has awarded this title to a Doctor of Podiatric Medicine, marking a historic moment for the field and highlighting the impact of his contributions to research, clinical care, and innovation.

Institute of Clinical & Translational Sciences at Washington University in St. Louis. https://translationalsciencebenefits.wustl.edu.

Community Education & Trust Leads to Health Improvements

Our local communities are at the heart of what we do. Our staff hold educational workshops and other offerings throughout LA with the goal of empowering community members to take control of their health through education and health promotion strategies.

As part of our commitment to supporting local communities, the CTSI Community Engagement Core hosted health fairs in East and South Los Angeles, offering free screenings, health education, and research opportunities to underserved residents during National Diabetes Month 2024. This initiative is just one example of how we partner with community organizations to reduce health disparities and promote wellness where it is needed most.

Disseminating our Success

Dissemination is a crucial aspect to the clinical research process, ensuring other researchers in the field and in local communities receive updates about our findings.

CTSI-affiliated faculty, staff and students presented 21 posters at 4 conferences nationally in 2024. View some of our short poster video presentations below.

Training and Metrics

Mentored Career Development in Clinical and Translational Science Program (KL2)

The Mentored Career Development in Clinical and Translational Science (MCD-CTS/KL2) is a three-year program that trains clinical and translational investigators to conduct rigorous, innovative and community engaged research that improves health and addresses disease burden in our local communities in the heart of Los Angeles.

The KL2 Mentored Career Development Program played a pivotal role in shaping Dr. Lorraine Kelley-Quon’s career as a principal investigator, enabling her to lead a landmark $7 million PCORI-funded clinical trial on opioid use in adolescents. Her journey from KL2 scholar to nationally recognized researcher and mentor exemplifies the program’s transformative impact on advancing clinician-scientists. Explore her article below, along with other impactful KL2 stories from 2024.

KL2 Highlights

SC CTSI training helps pediatric surgeon-scientist build career as primary investigator

SC CTSI's clinical and translational science-based educational courses and mentorship offerings help launch the careers of new researchers.

Passing down generational knowledge of gestational diabetes risk for children

Investigations sparked by SC CTSI pilot funding inspire a young research participant to pursue neuroscience as a career.

Early adolescents with chronic illness co-develop video prototypes to aid eventual transition to adult care

SC CTSI fellowship provided USC researcher with team science skills to study and improve mobile health interventions.

Training the Next Generation of Clinical and Translational Scientists

Workforce Development offers educational programs in clinical research methodology, team science, community-engaged research, research ethics, digital tools, and mentorship.

For the KL2 program, Workforce Development administers coursework, mentorship, and K-grant coaching for Scholars.

2024 KL2 Scholars Profiles

Atu Agawa, MD, MPH, MSCE
Assistant Professor, Gastroenterology, Hepatology & Nutrition, Pediatrics, Children’s Hospital Los Angeles

Dr. Atu Agawu is an Assistant Professor in the Division of Gastroenterology, Hepatology & Nutrition, Department of Pediatrics, Keck School of Medicine of USC and Children's Hospital Los Angeles, He completed his undergraduate degree from Yale University. He continued to obtain on to receive a doctoral degree in medicine, and Masters degrees in Public Health as well as Clinical Epidemiology from the University of Pennsylvania. His KL2 research focuses on health outcomes in children with medical complexity, specifically those with intestinal failure.

Alison Cogan, MA, PhD
Assistant Professor, Occupational Science and Occupational Therapy, Ostrow School of Dentistry

Dr. Alison Cogan is an Assistant Professor in the Mrs. T. H. Chan Division of Occupational Science and Occupational Therapy, Herman Ostrow School of Dentistry at the University of Southern California. She completed her undergraduate and MEd degrees from Temple University. She continued to receive her MA in Occupational Therapy and PhD in Occupational Science from the University of Southern California. As part of her KL2 research, Dr. Cogan will apply novel approaches to investigating functional recovery trajectories for adults with stroke and developing an in-depth picture of realtime clinical decision making among rehabilitation therapists in an inpatient post-acute care setting.

Albert Han, MD
Assistant Professor, Otolaryngology--Head and Neck Surgery, Keck School of Medicine

Dr. Albert Han is an Assistant Professor in the Department of Otolaryngology--Head and Neck Surgery at the Keck School of Medicine of USC. He completed his undergraduate degree at the University of California, Berkley and completed both a PhD and medical degree at the University of California, Los Angeles (UCLA). He complete his residency at UCLA's Medical Center and fellowship in Head and Neck Surgical Oncology at MD Anderson Cancer Center. As part of his KL2 research, he will aim to define the role of cancer-associated fibroblasts in HPV+ oropharyngeal squamous cell carcinoma carcinogenesis and progression.

Jeanine Hall, MD
Assistant Professor, Emergency and Transport Medicine Pediatrics, Children's Hospital Los Angeles

Dr. Jeanine Hall is an Assistant Professor within the Division of Emergency and Transport Medicine through the Department of Pediatrics at the University of Southern California and Children's Hospital Los Angeles. She completed her undergraduate degree at Xavier University of Louisiana, She obtained a medical degree from the University of Missouri, and completed her residency at Cincinnati Children’s Hospital Medical Center, and fellowship at Children’s Hospital Los Angeles. Dr. Hall completed her Masters in Public Health from the University of Southern California. She intends to focus on health services research to improve post-emergency department connections to care through the understanding of barriers to access to care and the design and implementation of innovative technologies and process to help ameliorate disparities in access to care.

Jeanine Yonashiro-Cho, MD
Assistant Professor, Family Medicine, Keck School of Medicine

Dr. Jeanine Yonashiro-Cho is an Assistant Professor within the Department of Family Medicine at the Keck School of Medicine of USC. She completed her undergraduate, Master of Science, and doctoral degrees at the University of Southern California. Her KL2 research will investigate the caregiving practices and cultural beliefs of Asian American and Pacific Islander (AAPI) dementia caregivers (many living in cultural enclaves in urban settings), applying these findings to inform the cultural adaptation of an existing caregiver activation and support intervention for use among AAPI dementia caregivers, and assessing intervention efficacy and feasibility through a randomized controlled trial.

Acknowledgments

The Southern California Clinical and Translational Science Institute (SC CTSI) is funded by the National Center for Advancing Translational Sciences at the NIH through the Clinical and Translational Science Awards (Award Number UL1TR001855). We are committed to turning discoveries into real-world treatments while engaging communities in research and training the next generation of clinical investigators. Our overarching goal is to support research that improves individual and public health, both in Southern California and beyond.

This 2024 Impact Report was compiled by Nicki Apaydin, PhD and Ivy Hoang, BS with data collected by the Evaluation & Improvement team. The work within reflects tremendous efforts made by all SC CTSI faculty and staff.

Thank you to all of our academic and community partners, research personnel, participants, faculty, and staff.

SC CTSI offers a range of services to researchers at USC and CHLA, including:

  • Education, training, and career development
  • Funding opportunities
  • Consultations in biostatistics, informatics, and healthcare delivery science
  • Informatics and EHR-based tools
  • Community engagement and partnership
  • Clinical research operations support and Clinical Research Units
  • Regulatory guidance and support

Learn more about the services we offer below.

The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.